Decreased interleukin 27 expression is associated with active uveitis in Behçet’s disease

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Decreased interleukin 27 expression is associated with active uveitis in Behçet’s disease

INSTRUCTION Interleukin 27 (IL-27) is an important regulator of the proinflammatory T-cell response. In this study, we investigated its role in the pathogenesis of Behçet's disease (BD). METHODS IL-27 mRNA in peripheral blood mononuclear cells (PBMCs) was examined by performing RT-PCRs. Cytokine levels in sera or supernatants of PBMCs, naïve CD4(+) T cells, dendritic cells (DCs) and DC/T cell...

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ژورنال

عنوان ژورنال: Arthritis Research & Therapy

سال: 2014

ISSN: 1478-6354

DOI: 10.1186/ar4570